The answer is no.
It’s not grammatically correct to put it this way. Instead, you should use one of the followings: I have …
a number of questions
a few questions
a couple of questions
a handful of questions
And the like…
Please note that the verb for “a number of” is always plural, and the verb for “the number of” is always singular.
In English, ‘numbers’ can be used to indicate the number of people attending an event or activity.