Tragedy
Tragedy (noun) /ˈtrædʒ.ə.di/
a very sad and painful event that involves death or suffering, or a play or literature that reflects suffering and sorrow, misfortune, disaster, calamity, heartbreak, catastrophe
His miserable life has been a complete tragedy replete with suffering and wretchedness.
Antonyms: comedy, joy
Adjective: tragic
Adverb: tragically